王洋
药物化学, 教授, 博士生导师


姓      名

王洋

性      别

职      称

教授

学      历

博士

电      话

021-51980115

传      真


电子邮件

 wangyang@shmu.edu.cn

个人主页


通讯地址

上海市浦东新区张衡路826号

教育经历


1985.09 – 1989.06 郑州大学化学系,本科

1989.09 – 1992.06 郑州大学化学系有机化学专业,硕士

2001.09 – 2005.06 澳门新葡亰www496cn药物化学专业,在职博士,获理学博士学位


     工作经历

       1992.07 – 1999.03  郑州大学化学系,助教、讲师(1995年)

       1993.09 – 1994.09  日本京都龍谷大学,访问学者
       1999.04 – 现在  澳门新葡亰www496cn药物化学教研室,副教授(2000年)、教授(2010年)
       2006.01 – 现在  兼任药学实验教学中心主任



获奖及荣誉

2019年   上海市育才奖

2015年  “宝钢优秀教师奖”

2013年   上海市教学成果二等奖(第二完成人)

2012年   葡京娛樂场APP“创先争优·教书育人”优秀共产党员称号


社会学术兼职

2011.10 – 现在  上海市药学会药物化学专业委员会委员


研究方向

活性天然产物的合成、结构改造与成药性研究


代表性论著


1. Liu, M.; Liang, Y.; Zhu, Z.; Wang, J.; Cheng, X.; Cheng, J.; Xu, B.; Li, R.; Liu, X.*; Wang, Y.* Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor (HIF) 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis, J. Med. Chem.2019,62, 9299-9314.  


2. Gao, F.; Liang, Y.; Zhou, P.; Cheng, J.; Ding, K.*; Wang, Y.* Design, Synthesis, Antitumor Activities and Biological Studies of Novel Diaryl Substituted Fused Heterocycles as Dual Ligands Targeting Tubulin and Katanin, Eur. J. Med. Chem.2019,178, 177-194.  


3. Zhou, P.; Liang, Y.; Zhang, H.; Jiang, H.; Feng, K.; Xu, P.; Wang, J.; Wang, X.; Ding, K.*; Luo, C.*; Liu, M.*; Wang, Y.* Design, Synthesis, Biological Evaluation and Cocrystal Structures with Tubulin of Chiral β-Lactam Bridged Combretastatin A-4 Analogues as Potent Antitumor Agents, Eur. J. Med. Chem.2018,144, 817-842.


4. Zhang M.; Liang, Y.-R.; Li, H.; Liu, M.-M.*; Wang, Y.* Design, Synthesis, and Biological Evaluation of Hydantoin Bridged Analogues of Combretastatin A-4 as Potential Anticancer Agents, Bioorg. Med. Chem. 2017,25, 6623-6634.


5. Sheng, X.; Jia, X.-Y.; Tang, F.; Wang, Y.*; Hou, A.-J.* The Total Synthesis of (±)-Sanggenol F, Tetrahedron 2017,73, 3485-3491.


6. Zhou, P.; Liu, Y.; Zhou, L.; Zhu, K.; Feng, K.; Zhang, H.; Liang, Y.; Jiang, H.; Luo, C.*; Liu, M.*; Wang, Y.* Potent Anti-tumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin, J. Med. Chem.2016,59, 10329-10334.


7. Wu, J. F.; Liu, M. M.; Huang, S. X.*; Wang, Y.* Design and Synthesis of Novel Substituted Naphthyridines as Potential c-Met Kinase Inhibitors Based on MK-2461, Bioorg. Med. Chem. Lett. 2015,25, 3251-3255.


8. Tang, F.; Wang, Y.*; Hou, A. J.* Total Syntheses of Nigrasin I and Kuwanon C, Tetrahedron2014,70, 3963-3970.


9. Zhang, W. J.; Wu, J. F.; Zhou, P. F.; Wang, Y.*; Hou, A. J.* Total Syntheses of Norartocarpin and Artocarpin, Tetrahedron2013,69, 5850-5858.


10. Jia, Y. L.; Dong, X. Y.; Zhou, P. F.; Liu, X. H.; Pan, L. L.; Xin, H.; Zhu, Y. Z.*; Wang, Y.* The Synthesis and Biological Evaluation of Novel Danshensu-cysteine Analog Conjugates as Cardiovascular-protective Agents, Eur. J. Med. Chem.2012,55, 176-187


11. Wang, J.; Zhou, P. F.; Wang, Y.* Selective sp3 C-H Bond Activation Based on Carbocation Relay: Friedel-Crafts Reaction with Alkane as the Alkylating Component, Eur. J. Org. Chem.2011, 264-270.


12. Zhang, J. L.; Wang, J.; Qiu, Z. B.*; Wang, Y.* Highly Regio- and Diastereoselective Halohydroxylation of Olefins: A Facile Synthesis of Vicinal Halohydrins, Tetrahedron2011,67, 6859-6867.




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